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Article

Characterization of the recognition of tumor cells by the natural cytotoxicity receptor, NKp44.

Biochemistry - 26 Jun 2007

Hershkovitz Oren, Jivov Sergey, Bloushtain Noga, Zilka Alon, Landau Guy, Bar-Ilan Ahuva, Lichtenstein Rachel G, Campbell Kerry S, van Kuppevelt Toin H, Porgador Angel

Abstract excerpt

NKp44 is a natural cytotoxicity receptor expressed by human NK cells upon activation. In this study, we demonstrate that cell surface heparan sulfate proteoglycans (HSPGs), expressed by target cells, are involved in the recognition of tumor cells by NKp44. NKp44 showed heparan sulfate-dependent binding to tumor cells; this binding was partially blocked with an antibody to heparan sulfate. In addition, direct...

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Carcinoma, Ductal
CHO Cells
Cricetulus
Heparitin Sulfate
Immunoglobulins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interferon-gamma

Killer Cells, Natural

Receptors, Immunologic

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PMID: 17536787
DOI: 10.1021/bi7000455

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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