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Article

Frequent BRAF mutations suggest a novel oncogenic driver in colonic neuroendocrine carcinoma.

Journal of surgical oncology - 1 Feb 2018

Idrees Kamran, Padmanabhan Chandrasekhar, Liu Eric, Guo Yan, Gonzalez Raul S, Berlin Jordan, Dahlman Kimberly B, Beauchamp R Daniel, Shi Chanjuan

Abstract excerpt

BACKGROUND AND OBJECTIVES: The World Health Organization (WHO) 2010 has classified GI neuroendocrine neoplasms into neuroendocrine tumor (NET) and high-grade neuroendocrine carcinoma (NEC). The genetic underpinnings of NEC are poorly understood. The aim of the study was to perform genomic profiling of NEC to better characterize this aggressive disease. METHODS: We identified nine patients with colonic NEC between...

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PMID: 28940307
DOI: 10.1002/jso.24834

Genes

BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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