Article
Gly388Arg FGFR4 Polymorphism Is Not Predictive of Everolimus Efficacy in Well-Differentiated Digestive Neuroendocrine Tumors.
Neuroendocrinology - 1 Jan 2016
Cros Jerome, Moati Emilie, Raffenne Jerome, Hentic Olivia, Svrcek Magali, de Mestier Louis, Sbidian Emilie, Guedj Nathalie, Bedossa Pierre, Paradis Valerie, Sauvanet Alain, Panis Yves, Ruszniewski Philippe, Couvelard Anne, Hammel Pascal
Abstract excerpt
INTRODUCTION: Preclinical data suggest that the single nucleotide polymorphism substituting a glycine for an arginine in codon 388 of the FGFR4 transmembrane domain may increase the proliferation of xenografted neuroendocrine cell lines and decrease their sensitivity to everolimus by modulating STAT3 signaling and the mTOR pathway. AIM: To evaluate the prognostic and predictive values of this polymorphism on...
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