Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Oral immunization with an rfaH mutant elicits protection against salmonellosis in mice.

Infection and immunity - 1 Jul 2004

Nagy Gábor, Dobrindt Ulrich, Hacker Jörg, Emödy Levente

Abstract excerpt

Loss of the transcriptional antiterminator RfaH results in virulence attenuation (>10(4)-fold increase in 50% lethal dose) of the archetypal Salmonella enterica serovar Typhimurium strain SL1344 by both orogastric and intraperitoneal routes of infection in BALB/c mice. Oral immunization with the mutant efficiently protects mice against a subsequent oral infection with the wild-type strain. Interestingly, in vitro...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Administration, Oral
Share to Escherichia coli Proteins
Share to Mice

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Peptide Elongation Factors

Share to Salmonella Infections, Animal

Share to Salmonella typhimurium

Share to Trans-Activators

Share to Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 15213179
DOI: 10.1128/IAI.72.7.4297-4301.2004
PMCID: PMC427435

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oral immunization with an rfaH mutant elicits protection against salmonellosis in mice.PMID 15213179Read ↗

Down-regulation of key virulence factors makes the Salmonella enterica serovar Typhimurium rfaH mutant a promising live-attenuated vaccine candidate.Semantic proximity Read ↗

Transcriptional regulation through RfaH contributes to intestinal colonization by Escherichia coli.Semantic proximity Read ↗

RfaH promotes the ability of the avian pathogenic Escherichia coli O2 strain E058 to cause avian colibacillosis.Semantic proximity Read ↗

The Salmonella effector AvrA mediates bacterial intracellular survival during infection in vivoSemantic proximity Read ↗

Evaluation of Salmonella typhimurium strains harbouring defined mutations in htrA and aroA in the murine salmonellosis model.Semantic proximity Read ↗

Salmonella enterica Serovar Typhimurium Lacking hfq Gene Confers Protective Immunity against Murine TyphoidSemantic proximity Read ↗

Virulence and vaccine potential of Salmonella typhimurium mutants deficient in the expression of the RpoS (sigma S) regulon.Semantic proximity Read ↗

A Live Oral Fowl Typhoid Vaccine with Reversible O-Antigen Production.Semantic proximity Read ↗

Characterization of candidate live oral Salmonella typhi vaccine strains harboring defined mutations in aroA, aroC, and htrA.Semantic proximity Read ↗

The Salmonella Enteritidis lipopolysaccharide biosynthesis gene rfbH is required for survival in egg albumen.Semantic proximity Read ↗

Evaluation of Protective Efficacy of Live Attenuated Salmonella enterica Serovar Gallinarum Vaccine Strains against Fowl Typhoid in ChickensSemantic proximity Read ↗

Salmonella enterica serovar typhimurium trxA mutants are protective against virulent challenge and induce less inflammation than the live-attenuated vaccine strain SL3261.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.