Article
p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors.
Proceedings of the National Academy of Sciences of the United States of America - 30 May 2006
Keyes William M, Vogel Hannes, Koster Maranke I, Guo Xuecui, Qi Yi, Petherbridge Kristin M, Roop Dennis R, Bradley Allan, Mills Alea A
Abstract excerpt
Homology between p63 and p53 has suggested that these proteins might function similarly. However, the majority of data from human tumors have not supported a similar role for p63 in tumor suppression. To investigate this issue, we studied spontaneous tumorigenesis in p63+/- mice in both WT and p53-compromised backgrounds. We found that p63+/- mice were not tumor prone and mice heterozygous for both p63 and p53...
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