An association between the methylenetetrahydrofolate reductase (MTHFR) C677T mutation and inflammation markers related to cardiovascular disease.

doi:10.1016/j.ijcard.2004.08.038

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Article

An association between the methylenetetrahydrofolate reductase (MTHFR) C677T mutation and inflammation markers related to cardiovascular disease.

International journal of cardiology - 28 Apr 2005

Dedoussis George V Z, Panagiotakos Demosthenes B, Pitsavos Christos, Chrysohoou Christina, Skoumas John, Choumerianou Despoina, Stefanadis Christodoulos

Abstract excerpt

BACKGROUND: Prospective studies have identified many markers of systemic inflammation that are powerful predictors of future cardiovascular events. The methylenetetrahydrofolate reductase (MTHFR) C677T genotype, a common polymorphism that induces hyperhomocysteinaemia, has been proposed as a gene...

Topics

C-Reactive Protein
Cardiovascular Diseases
Cross-Sectional Studies
Female
Fibrinogen
Genotype
Homocysteine
Humans
Methylenetetrahydrofolate Reductase (NADPH2)
Middle Aged
Mutation
Polymorphism, Genetic
Serum Amyloid A Protein

Source

Open in PubMed

Identifiers

PMID: 15837084
DOI: 10.1016/j.ijcard.2004.08.038

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-15837084-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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