Article
Lith genes control mucin accumulation, cholesterol crystallization, and gallstone formation in A/J and AKR/J inbred mice.
Hepatology (Baltimore, Md.) - 1 Nov 2002
Lammert Frank, Wang David Q-H, Wittenburg Henning, Bouchard Guylaine, Hillebrandt Sonja, Taenzler Bärbel, Carey Martin C, Paigen Beverly
Abstract excerpt
We recently identified 2 Lith genes that determine cholesterol gallstone formation in C57L/J inbred mice, which show a gallstone prevalence of approximately 80% on feeding 1.0% cholesterol and 0.5% cholic acid. The aim of this study was to explore if the same Lith loci contribute to the variation in gallstone susceptibility in a new experimental cross. After 12 weeks of feeding the lithogenic diet to inbred mice...
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