Article
Quantitative trait loci mapping for cholesterol gallstones in AKR/J and C57L/J strains of mice.
Physiological genomics - 9 Nov 2000
Paigen B, Schork N J, Svenson K L, Cheah Y C, Mu J L, Lammert F, Wang D Q, Bouchard G, Carey M C
Abstract excerpt
Quantitative trait locus (QTL) mapping was used to locate genes that determine the difference in cholesterol gallstone disease between the gallstone-susceptible strain C57L/J and the gallstone-resistant strain AKR/J. Gallstone weight was determined in 231 male (AKR x C57L) F(1) x AKR backcross mice fed a lithogenic diet containing 1% cholesterol, 0.5% cholic acid, and 15% butterfat for 8 wk. Mice having no stones...
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