Article
The hemochromatosis C282Y allele: a risk factor for hepatic veno-occlusive disease after hematopoietic stem cell transplantation.
Bone marrow transplantation - 1 Jun 2005
Kallianpur A R, Hall L D, Yadav M, Byrne D W, Speroff T, Dittus R S, Haines J L, Christman B W, Summar M L
Abstract excerpt
Hepatic veno-occlusive disease (HVOD) is a serious complication of hematopoietic stem cell transplantation (HSCT). Since the liver is a major site of iron deposition in HFE-associated hemochromatosis, and iron has oxidative toxicity, we hypothesized that HFE genotype might influence the risk of HVOD after myeloablative HSCT. We determined HFE genotypes in 166 HSCT recipients who were evaluated prospectively for...
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