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Article

The prognostic role of hemochromatosis H63D allele in allogeneic hematopoietic stem cell transplantation.

Annals of hematology - 1 Aug 2012

Sucak Gülsan Türköz, Yaşar Demet Gökalp, Yegin Zeynep Arzu, Ergün Mehmet Ali, Ozkurt Zübeyde Nur, Aki Şahika Zeynep, Güntekin Sezen

Abstract excerpt

Iron overload is considered as a significant cause of morbidity and mortality in hematopoietic stem cell transplant (HSCT) recipients. The presence of hemochromatosis gene (HFE) mutations might exacerbate iron toxicity in the post-transplant setting. This prospective study was planned to evaluate the genetic spectrum of HFE mutations in Turkish patients undergoing HSCT and the impact of HFE genotype on transplant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22362121
DOI: 10.1007/s00277-012-1428-z

Genes

HFE

Provenance

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Related research

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The prognostic role of hemochromatosis H63D allele in allogeneic hematopoietic stem cell transplantation.PMID 22362121Read ↗

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Incidence of a clinically relevant H63D syndrome in carriers of a homozygous mutation of HFE gene H63DSemantic proximity Read ↗

HFE gene mutation and iron overload in Egyptian pediatric acute lymphoblastic leukemia survivors: a single-center study.Semantic proximity Read ↗

Frequency of Hereditary Hemochromatosis (HFE) Gene Mutations in Egyptian Beta Thalassemia Patients and its Relation to Iron OverloadSemantic proximity Read ↗

The hemochromatosis C282Y allele: a risk factor for hepatic veno-occlusive disease after hematopoietic stem cell transplantation.Semantic proximity Read ↗

Clinical impact of HFE mutations in Japanese patients with chronic hepatitis C.Semantic proximity Read ↗

Compound heterozygosity for haemochromatosis gene mutations and hepatic iron overload in allogeneic bone marrow transplant recipients.Semantic proximity Read ↗

Individuals homozygous for the H63D mutation have significantly elevated iron indexes.Semantic proximity Read ↗

Effect of Hereditary Hemochromatosis Gene H63D and C282Y Mutations on Iron Overload in Sickle Cell Disease Patients.Semantic proximity Read ↗

HFE genetic variability and risk of alcoholic liver disease: A meta-analysis.Semantic proximity Read ↗

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