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Article

Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase.

Nature cell biology - 1 May 2005

Lau Alan, Swinbank Karra M, Ahmed Parvin S, Taylor Debra L, Jackson Stephen P, Smith Graeme C M, O'Connor Mark J

Abstract excerpt

Chemotherapy that is used to treat human immunodeficiency virus type-1 (HIV-1) infection focuses primarily on targeting virally encoded proteins. However, the combination of a short retroviral life cycle and high mutation rate leads to the selection of drug-resistant HIV-1 variants. One way to address this problem is to inhibit non-essential host cell proteins that are required for viral replication. Here we show...

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Source

Identifiers

PMID: 15834407
DOI: 10.1038/ncb1250

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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