Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel HIV-1 therapeutics through targeting altered host cell pathways

7 Sept 2009

Abstract excerpt

The emergence of drug-resistant HIV-1 strains presents a challenge for the design of new drugs. Anti-HIV compounds currently in use are the subject of advanced clinical trials using either HIV-1 reverse transcriptase, viral protease or integrase inhibitors. Recent studies show an increase in the number of HIV-1 variants resistant to anti-retroviral agents in newly infected individuals. Targeting host cell factors...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV/AIDS drug development and treatment
Share to HIV Research and Treatment
Share to RNA Interference and Gene Delivery

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19732026
DOI: 10.1517/14712590903257781

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Novel HIV-1 therapeutics through targeting altered host cell pathwaysPMID 19732026Read ↗

Interference with p53 functions in human viral infections, a target for novel antiviral strategies?Semantic proximity Read ↗

Herpes simplex virus type 1 abrogates the antiviral activity of Ch25h via its virion host shutoff proteinSemantic proximity Read ↗

Guanidine alkaloid analogs as inhibitors of HIV-1 Nef interactions with p53, actin, and p56 <sup>lck</sup>Semantic proximity Read ↗

Targeting the Human DEAD-Box Polypeptide 3 (DDX3) RNA Helicase as a Novel Strategy to Inhibit Viral ReplicationSemantic proximity Read ↗

Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase.Semantic proximity Read ↗

Microarray study reveals that HIV-1 induces rapid type-I interferon-dependent p53 mRNA up-regulation in human primary CD4+T cellsSemantic proximity Read ↗

Medicinal chemistry strategies toward host targeting antiviral agentsSemantic proximity Read ↗

Novel targets for anti-retroviral therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.