Article
Frequency analysis of the delta32ccr5 HIV resistance allele in a medieval plague mass grave.
Anthropologischer Anzeiger; Bericht uber die biologisch-anthropologische Literatur - 1 Mar 2005
Kremeyer Barbara, Hummel Susanne, Herrmann Bernd
Abstract excerpt
The 32 basepair deletion in the gene for the human chemokine receptor CCR5 (delta32ccr5) conferring resistance against HIV-1 infection is present in Caucasian populations. The mutant allele is believed to have originated by a single mutational event in historic times and to have reached its present population frequency of an average 10 % in Europe through selective pressure by a pathogenic agent. Because of their...
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