Recombinant adenoviruses expressing steatosis-associated hepatitis C virus genotype 3 core protein produce intracellular lipid accumulation in cultured and primary hepatocytes.

Abstract excerpt

Steatosis, or "fatty liver", is a common finding in Hepatitis C virus (HCV) infection and reflects dysregulation of lipid homeostasis. HCV Core protein causes lipid accumulation when expressed in cultured cell lines, which data now indicates is a critical step for HCV replication, assembly and release. Previous studies on HCV Core and lipid accumulation have been limited by poor efficiency of conventional...

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