Article
Adjusting data to body size: a comparison of methods as applied to quantitative trait loci analysis of musculoskeletal phenotypes.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 May 2005
Lang Dean H, Sharkey Neil A, Lionikas Arimantas, Mack Holly A, Larsson Lars, Vogler George P, Vandenbergh David J, Blizard David A, Stout Joseph T, Stitt Joseph P, McClearn Gerald E
Abstract excerpt
UNLABELLED: The aim of this study was to compare three methods of adjusting skeletal data for body size and examine their use in QTL analyses. It was found that dividing skeletal phenotypes by body mass index induced erroneous QTL results. The preferred method of body size adjustment was multiple regression. INTRODUCTION: Many skeletal studies have reported strong correlations between phenotypes for muscle, bone,...
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