Article
Genetic variants in the vitamin D receptor gene and prostate cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Apr 2005
Hayes Vanessa M, Severi Gianluca, Padilla Emma J D, Eggleton Sarah A, Southey Melissa C, Sutherland Robert L, Hopper John L, Giles Graham G
Abstract excerpt
Vitamin D receptor (VDR), a member of the steroid/thyroid hormone nuclear receptor family, is bound by the steroid hormone 1,25-dihydroxyvitamin D3, which is thought to play a role in the etiology and progression of prostate cancer. Polymorphisms in the VDR gene have been associated with prostate cancer risk, although findings are inconclusive. The purpose of this study was to determine if VDR polymorphisms were...
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