Article
Repression of the H5 histone gene by a factor from erythrocytes that binds to the region of transcription initiation.
The EMBO journal - 1 May 1992
Gómez-Cuadrado A, Rousseau S, Renaud J, Ruiz-Carrillo A
Abstract excerpt
Expression of histone H5, like that of other erythrocyte specific proteins, declines during the latter stages of erythroid maturation because of a decrease in the rate of gene transcription. Here, we report the isolation of cIBR (chicken initiation binding repressor), a 75 kDa DNA binding glycoprotein from mature chicken erythrocytes that recognizes sequences spanning the transcription start sites of the H5 gene....
Topics
- Animals
- Base Sequence
- Chickens
- Erythrocytes
- Histones
- Methylation
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- Repressor Proteins
- TATA Box