Article
Initiation of transcription of the erythroid promoter of the porphobilinogen deaminase gene is regulated by a cis-acting sequence around the cap site.
Nucleic acids research - 25 Nov 1990
Beaupain D, Eléouët J F, Roméo P H
Abstract excerpt
Although the erythroid-specific promoter of human porphobilinogen deaminase [PBGD] gene has no TATA box, transcription is initiated at a single nucleotide. Using 5' and 3' deletions and point mutations, we have identified an element, located around the initiation site, which is necessary and suff...
Topics
- Animals
- Base Sequence
- DNA
- Erythroid Precursor Cells
- Gene Expression Regulation
- HeLa Cells
- Humans
- Hydroxymethylbilane Synthase
- Mice
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- RNA Caps
- Regulatory Sequences, Nucleic Acid
- Sequence Homology, Nucleic Acid
- Transcription, Genetic