Article
Differential selection and mutation between dsDNA and ssDNA phages shape the evolution of their genomic AT percentage.
BMC genetics - 11 Apr 2005
Xia Xuhua, Yuen Kwok Yung
Abstract excerpt
BACKGROUND: Bacterial genomes differ dramatically in AT%. We have developed a model to show that the genomic AT% in rapidly replicating bacterial species can be used as an index of the availability of nucleotides A and T for DNA replication in cellular medium. This index is then used to (1) study the evolution and adaptation of the bacteriophage genomic AT% in response to the differential nucleotide availability...
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