Hypermutability of integrated sequences of viral origin in a chlorarachniophyte.

Abstract excerpt

Mutations provide the raw material for evolution, but mutation rates are not uniform across genomes. Using a mutation accumulation experiment in the marine phytoplankton Bigelowiella natans, we found extreme local variation in mutation rate: over 1,000-fold differences across its nuclear genome. While the baseline single-nucleotide mutation rate is approximately 3.5 × 10-10 per site per generation, a common value...

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