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Article

Potential role for human cytochrome P450 3A4 in estradiol homeostasis.

Endocrinology - 1 Jul 2005

Yu Ai-Ming, Fukamachi Katsumi, Krausz Kristopher W, Cheung Connie, Gonzalez Frank J

Abstract excerpt

Previously, a human CYP3A4-transgenic (Tg-CYP3A4) mouse line was reported to exhibit enhanced metabolism of midazolam by cytochrome P450 3A4 (CYP3A4) expressed in small intestine. Here we show that expression of CYP3A4 and murine cyp3a and cyp2b was both age and sex dependent. CYP3A4 was expressed in the livers of male and female Tg-CYP3A4 mice at 2 and 4 wk of age. Since 6 wk, CYP3A4 was undetectable in male...

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Identifiers

PMID: 15817670
DOI: 10.1210/en.2004-1248

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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