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Article

Thalidomide-induced limb abnormalities in a humanized CYP3A mouse model

23 Feb 2016

Abstract excerpt

Thalidomide is a teratogen in humans but not in rodents. It causes multiple birth defects including malformations of limbs, ears, and other organs. However, the species-specific mechanism of thalidomide teratogenicity is not completely understood. Reproduction of the human teratogenicity of thalidomide in rodents has previously failed because of the lack of a model reflecting human drug metabolism. In addition,...

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PMID: 26903378
DOI: 10.1038/srep21419

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