Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Investigation of Drug-Drug Interactions Caused by Human Pregnane X Receptor-Mediated Induction of CYP3A4 and CYP2C Subfamilies in Chimeric Mice with a Humanized Liver

1 Dec 2011

Abstract excerpt

No abstract is available from the source.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Transport and Resistance Mechanisms
Share to Hormonal Regulation and Hypertension
Share to Pharmacogenetics and Drug Metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22126990
DOI: 10.1124/dmd.111.042754

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Investigation of Drug-Drug Interactions Caused by Human Pregnane X Receptor-Mediated Induction of CYP3A4 and CYP2C Subfamilies in Chimeric Mice with a Humanized LiverPMID 22126990Read ↗

The Pregnane X Receptor Gene-Humanized Mouse: A Model for Investigating Drug-Drug Interactions Mediated by Cytochromes P450 3ASemantic proximity Read ↗

P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and ToxicitySemantic proximity Read ↗

Quantitative Prediction of Human Pregnane X Receptor and Cytochrome P450 3A4 Mediated Drug-Drug Interaction in a Novel Multiple Humanized Mouse LineSemantic proximity Read ↗

An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical TrialsSemantic proximity Read ↗

Application of Chimeric Mice with Humanized Liver for Study of Human-Specific Drug MetabolismSemantic proximity Read ↗

A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicitySemantic proximity Read ↗

Mice as Clinically Relevant Models for the Study of Cytochrome P450-dependent MetabolismSemantic proximity Read ↗

A human and mouse pregnane X receptor reporter gene assay in combination with cytotoxicity measurements as a tool to evaluate species-specific CYP3A inductionSemantic proximity Read ↗

A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.Semantic proximity Read ↗

Chimeric Mice with Humanized Livers: A Unique Tool for in Vivo and in Vitro Enzyme Induction StudiesSemantic proximity Read ↗

Investigation of Biotransformation Pathways in a Chimeric Mouse with a Humanized LiverSemantic proximity Read ↗

Impact of sex and pregnancy on hepatic CYP3A4 expression and activity in a humanized mouse modelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.