Article
Allogeneic stem-cell transplantation may overcome the adverse prognosis of unmutated VH gene in patients with chronic lymphocytic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 May 2005
Moreno Carol, Villamor Neus, Colomer Dolors, Esteve Jordi, Martino Rodrigo, Nomdedéu Josep, Bosch Francesc, López-Guillermo Armando, Campo Elías, Sierra Jorge, Montserrat Emili
Abstract excerpt
PURPOSE: To investigate whether allogeneic stem-cell transplantation (allo-SCT) may overcome the negative impact of unmutated VH genes in the outcome of patients with chronic lymphocytic leukemia (CLL). PATIENTS AND METHODS: We analyzed the outcome of patients who underwent SCT according to their VH mutational status. RESULTS: Thirty-four patients (14 allo-SCT and 20 autologous SCT [auto-SCT]) presented unmutated...
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