Allogeneic transplant with reduced intensity conditioning regimens may overcome the poor prognosis of B-cell chronic lymphocytic leukemia with unmutated immunoglobulin variable heavy-chain gene and chromosomal abnormalities (11q- and 17p-).

doi:10.1158/1078-0432.CCR-05-0941

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Allogeneic transplant with reduced intensity conditioning regimens may overcome the poor prognosis of B-cell chronic lymphocytic leukemia with unmutated immunoglobulin variable heavy-chain gene and chromosomal abnormalities (11q- and 17p-).

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2005

Caballero Dolores, García-Marco Jose A, Martino Rodrigo, Mateos Victoria, Ribera José M, Sarrá José, León Angel, Sanz Guillermo, de la Serna Javier, Cabrera Rafael, González Marcos, Sierra Jorge, San Miguel Jesús

Abstract excerpt

PURPOSE: To evaluate the efficacy of reduced intensity conditioning (RIC) allogeneic transplant in 30 patients with poor-prognosis chronic lymphocytic leukemia (CLL) and/or high-risk molecular/cytogenetic characteristics. EXPERIMENTAL DESIGN: Eighty-three percent of patients had active disease at the moment of transplant. That is, 14 of the 23 patients analyzed (60%) had unmutated immunoglobulin variable...

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PMID: 16278397
DOI: 10.1158/1078-0432.CCR-05-0941

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