Article
On the conservative nature of intragenic recombination.
Proceedings of the National Academy of Sciences of the United States of America - 12 Apr 2005
Drummond D Allan, Silberg Jonathan J, Meyer Michelle M, Wilke Claus O, Arnold Frances H
Abstract excerpt
Intragenic recombination rapidly creates protein sequence diversity compared with random mutation, but little is known about the relative effects of recombination and mutation on protein function. Here, we compare recombination of the distantly related beta-lactamases PSE-4 and TEM-1 to mutation of PSE-4. We show that, among beta-lactamase variants containing the same number of amino acid substitutions, variants...
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