Article
Intracellular detection of macrophage migration inhibitory factor in peripheral blood leukocytes.
Free radical biology & medicine - 1 May 2005
Lehmann Lutz E, Weber Stefan U, Fuchs Dagmar, Klaschik Sven, Schewe Jens Christian, Book Malte, Hoeft Andreas, Stüber Frank
Abstract excerpt
The oxidoreductase MIF is currently discussed as a new promising target of immunomodulatory therapy in patients with severe sepsis. An increasing body of evidence attributes an important role especially to intracellular MIF for regulation of endotoxin responsiveness as well as regulation of nuclear transcription factors. Up to now, measurement of MIF relied on ELISA techniques, lacking the ability to directly...
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