Article
Expression of cytolytic mediators by synovial fluid lymphocytes in rheumatoid arthritis.
The American journal of pathology - 1 May 1992
Young L H, Joag S V, Lin P Y, Luo S F, Zheng L M, Liu C C, Young J D
Abstract excerpt
To understand the role of cytolytic lymphocytes in the pathogenesis of rheumatoid arthritis, we investigated the expression of lymphocyte cytotoxicity mediators, perforin, and serine esterases, in lymphocytes derived from the synovial fluid of 15 patients with rheumatoid arthritis. Previous work has shown that CD8+ lymphocytes that possess markers of activation appear to be present in rheumatoid arthritis (RA)....
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