Peripheral blood but not synovial fluid natural killer T cells are biased towards a Th1-like phenotype in rheumatoid arthritis.

doi:10.1186/ar1695

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Article

Peripheral blood but not synovial fluid natural killer T cells are biased towards a Th1-like phenotype in rheumatoid arthritis.

Arthritis research & therapy - 1 Jan 2005

Linsen Loes, Thewissen Marielle, Baeten Kurt, Somers Veerle, Geusens Piet, Raus Jef, Stinissen Piet

Abstract excerpt

Natural killer T (NKT) cells have been implicated in the regulatory immune mechanisms that control autoimmunity. However, their precise role in the pathogenesis of rheumatoid arthritis (RA) remains unclear. The frequency, cytokine profile and heterogeneity of NKT cells were studied in peripheral blood mononuclear cells (PBMCs) from 23 RA patients and 22 healthy control individuals, including paired PBMC-synovial...

Topics

Adult
Aged
Arthritis, Rheumatoid
Cells, Cultured
Female
Humans
Killer Cells, Natural
Leukocytes, Mononuclear
Male
Middle Aged
Phenotype
Synovial Fluid
Th1 Cells

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Identifiers

PMID: 15899036
DOI: 10.1186/ar1695
PMCID: PMC1174940

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