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XRCC1 Arg399Gln Genetic Variant Increases Colorectal Cancer Susceptibility: A Comprehensive Meta-Analysis.

Asian Pacific journal of cancer prevention : APJCP - 1 Nov 2025

Kampalli Praveen Kumar, Ghanta Mohan Krishna, Mavillapalli Rishitha Chowdary, Alam Afroz, Peela Sujatha, Bhaskar Lvks

Abstract excerpt

INTRODUCTION: Colorectal cancer (CRC) continues to be a common health condition and one of the most prevalent and lethal cancers worldwide. CRC is the third most leading cancer by incidence and second most common cause of cancer mortality. Emerging evidence showing that inherited genetic variants in genes coding for DNA repair enzymes have potential role in increasing the risk of CRC. Among these, polymorphisms...

Topics

Humans
X-ray Repair Cross Complementing Protein 1
Colorectal Neoplasms
Genetic Predisposition to Disease
Case-Control Studies
Prognosis
Polymorphism, Single Nucleotide
Risk Factors
DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

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Open in PubMed Open full text

Identifiers

PMID: 41312940
DOI: 10.31557/APJCP.2025.26.11.4127
PMCID: PMC12948178

Genes

XRCC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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XRCC1 Arg399Gln Genetic Variant Increases Colorectal Cancer Susceptibility: A Comprehensive Meta-Analysis.PMID 41312940Read ↗

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