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Article

Connexin43 is overexpressed in Apc(Min/+)-mice adenomas and colocalises with COX-2 in myofibroblasts.

International journal of cancer - 1 Sept 2005

Husøy Trine, Knutsen Helle K, Cruciani Véronique, Olstørn Hege B, Mikalsen Svein-Ole, Løberg Else Marit, Alexander Jan

Abstract excerpt

The expression of gap junction proteins, connexins, in the intestine and their role in tumorigenesis are poorly characterised. Truncating mutations in the tumour suppressor gene adenomatous polyposis coli (APC) are early and important events, both in inheritable (familial adenomatous polyposis, FAP) and spontaneous forms of intestinal cancer. Multiple intestinal neoplasia (Min) mice, a FAP model with inherited...

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Source

Identifiers

PMID: 15800939
DOI: 10.1002/ijc.21025

Genes

FAP
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Connexin43 is overexpressed in Apc(Min/+)-mice adenomas and colocalises with COX-2 in myofibroblasts.PMID 15800939Read ↗

Intestinal adenomas of Min-mice lack enterochromaffin cells, and have increased lysozyme production in non-Paneth cells.Semantic proximity Read ↗

Cells heterozygous for the ApcMin mutation have decreased gap junctional intercellular communication and connexin43 level, and reduced microtubule polymerization.Semantic proximity Read ↗

Apc deficiency is associated with increased Egfr activity in the intestinal enterocytes and adenomas of C57BL/6J-Min/+ mice.Semantic proximity Read ↗

Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the Apc(Min/+) mouse.Semantic proximity Read ↗

Multistep carcinogenesis of the colon in Apc(Min/+) mouse.Semantic proximity Read ↗

Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways.Semantic proximity Read ↗

Deletion of the WNT Target and Cancer Stem Cell Marker CD44 in Apc(Min/+) Mice Attenuates Intestinal TumorigenesisSemantic proximity Read ↗

Progressive changes in adherens junction structure during intestinal adenoma formation in Apc mutant mice.Semantic proximity Read ↗

Inhibition of Intestinal Polyposis with Reduced Angiogenesis in ApcMin/+ Mice Due to Decreases in c-Myc ExpressionSemantic proximity Read ↗

Microadenomatous lesions involving loss of Apc heterozygosity in the colon of adult Apc(Min/+) mice.Semantic proximity Read ↗

Qualitative and quantitative relationship between dysplastic aberrant crypt foci and tumorigenesis in the Min/+ mouse colon.Semantic proximity Read ↗

Intestinal-specific PPARgamma deficiency enhances tumorigenesis in ApcMin/+ mice.Semantic proximity Read ↗

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