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Article

Matrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development.

Molecular and cellular biology - 1 Apr 2005

Little Christopher B, Meeker Clare T, Hembry Rosalind M, Sims Natalie A, Lawlor Kate E, Golub Sue B, Last Karena, Fosang Amanda J

Abstract excerpt

The growth plate is a transitional region of cartilage and highly diversified chondrocytes that controls long bone formation. The composition of growth plate cartilage changes markedly from the epiphysis to the metaphysis, notably with the loss of type II collagen, concomitant with an increase in MMP-13; type X collagen; and the C-propeptide of type II collagen. In contrast, the fate of aggrecan in the growth...

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Identifiers

PMID: 15798221
DOI: 10.1128/MCB.25.8.3388-3399.2005
PMCID: PMC1069612

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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