Article
Haplotype-based case-control study revealing an association between the adrenomedullin gene and proteinuria in subjects with essential hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Mar 2005
Kobayashi Yujin, Nakayama Tomohiro, Sato Naoyuki, Izumi Yoichi, Kokubun Shinichiro, Soma Masayoshi
Abstract excerpt
Adrenomedullin (AM) has various physiological actions on the cardiovascular system, including vasodilatation, diuresis, natriuresis, inhibition of aldosterone secretion, and increases of the cardiac output, all of which cause hypotension. Since AM plays a role in the pathophysiology of vascular diseases, genes controlling AM might be involved in the development and etiology of essential hypertension (EH)....
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