Human glutathion S-transferase A1 polymorphism and susceptibility to urothelial cancer in the Japanese population.

Abstract excerpt

GSTA1 has been reported to be most efficient in detoxifying N-acetoxy PhIP. In this study, 341 Japanese urothelial cancer patients and 457 healthy controls were compared for frequencies of GSTA1 genotype. We present the first evidence of an association between GSTA1*B (-567G, -69T, -52A) and urothelial cancer among never smokers. The frequency of GSTA1 *A/*B or *B/*B genotype was 24.3% in urothelial cancer cases,...

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