Article
GSTM1, GSTT1 and GSTP1 Genetic Variants in Multiple Urologic Cancers.
Chirurgia (Bucharest, Romania : 1990) - 1 Jan 2000
Chirilă D N, Popp R, Vesa Ș, Bălăcescu O, Coman I, Constantea N A, Ciuce C
Abstract excerpt
INTRODUCTION: Glutathione S-transferases (GSTs) are phase 2 enzymes responsible for catalyzing the biotransformation of a wide variety of electrophilic compounds, having a crucial role in the detoxification of active metabolites of procarcinogens produced by phase 1 reactions, tying them to glutathione and promoting their excretion in the urine. OBJECTIVES: we evaluated GSTM1, GSTT1 and GSTP1 genotypes in...
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