Article
Vascular damage by unstable hemoglobins: the role of heme-depleted globin.
Archives of biochemistry and biophysics - 15 Apr 2005
Tsemakhovich V A, Bamm V V, Shaklai M, Shaklai N
Abstract excerpt
The study compared the damage inflicted to endothelial cells (ECs) by intact hemoglobin (Hb) and isolated chains. To compare optional in vivo contact of acellular Hb with the endothelium, oxy-forms of Hb and its isolated alpha- and beta-chains existing in the thalassemias were added to primary confluent cultures of bovine aorta EC. Cell damage was followed by morphological changes or leakage of lactic...
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