Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Preclinical In Vitro Safety Investigations of Submicron Sized Hemoglobin Based Oxygen Carrier HbMP-700.

Artificial organs - 1 May 2018

Kao Ijad, Xiong Yu, Steffen Axel, Smuda Kathrin, Zhao Lian, Georgieva Radostina, Pruss Axel, Bäumler Hans

Abstract excerpt

Hemoglobin-based oxygen carriers (HBOCs) are being developed as oxygen and plasma volume-expanding therapeutics though their potential to promote oxidative tissue injury and nitric oxide (NO) scavenging combined with vasoconstriction has raised safety concerns. Therefore, we focused on these aspects during preclinical studies performed with the recently introduced hemoglobin microparticles (HbMP-700). Besides...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacteria
Share to Cell Line
Share to DNA Damage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemoglobins

Share to Oxidative Stress

Share to Particle Size

Share to Reactive Oxygen Species

Share to Vasoconstriction

Source

Identifiers

PMID: 29508415
DOI: 10.1111/aor.13071

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Preclinical In Vitro Safety Investigations of Submicron Sized Hemoglobin Based Oxygen Carrier HbMP-700.PMID 29508415Read ↗

Silk Fibroin Particles as Carriers in the Development of All-Natural Hemoglobin-Based Oxygen Carriers (HBOCs)Semantic proximity Read ↗

Red blood cell-derived microparticles: An overviewSemantic proximity Read ↗

Osivelotor for the treatment of sickle cell diseaseSemantic proximity Read ↗

Therapeutic potential of oxygen through M101 transportation in reducing vaso-occlusion and hemolysis in a mouse model of sickle cell diseaseSemantic proximity Read ↗

Exploring Oxidative Reactions in Hemoglobin Variants Using Mass Spectrometry: Lessons for Engineering Oxidatively Stable Oxygen Therapeutics.Semantic proximity Read ↗

Vascular damage by unstable hemoglobins: the role of heme-depleted globin.Semantic proximity Read ↗

Semisynthesis of hemoglobin.Semantic proximity Read ↗

Semisynthesis of hemoglobin.Semantic proximity Read ↗

Endothelium Response to Iron Sucrose Nanoparticles in Static Versus Dynamic Culture ModelSemantic proximity Read ↗

Arriving at a Number: What Hemoglobin S Level to Select During an Emergent RBC Exchange for Patients on Voxelotor.Semantic proximity Read ↗

Redox properties of human hemoglobin in complex with fractionated dimeric and polymeric human haptoglobin.Semantic proximity Read ↗

Characterizing blood microparticles: technical aspects and challenges.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.