Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tau is not normally degraded by the proteasome.

Journal of neuroscience research - 1 May 2005

Feuillette Sébastien, Blard Olivier, Lecourtois Magalie, Frébourg Thierry, Campion Dominique, Dumanchin Cécile

Abstract excerpt

Tau-positive inclusions in neurons are consistent neuropathologic features of the most common causes of dementias such Alzheimer's disease and frontotemporal dementia. Ubiquitinated tau-positive inclusions have been reported in brains of Alzheimer's disease patients, but involvement of the ubiquitin-dependent proteasomal system in tau degradation remains controversial. Before considering the tau degradation in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drosophila melanogaster
Share to Enzyme Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Silencing

Share to Neurofibrillary Tangles

Share to Proteasome Endopeptidase Complex

Share to Proteasome Inhibitors

Share to tau Proteins

Share to Tauopathies

Source

Identifiers

PMID: 15795929
DOI: 10.1002/jnr.20414

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tau is not normally degraded by the proteasome.PMID 15795929Read ↗

Review: The ubiquitin-proteasome system: contributions to cell death or survival in neurodegenerationSemantic proximity Read ↗

A caspase cleaved form of tau is preferentially degraded through the autophagy pathway.Semantic proximity Read ↗

Proteasomal degradation of tau proteinSemantic proximity Read ↗

The ubiquitin-proteasome system and neurodegenerative disorders.Semantic proximity Read ↗

The role of the ubiquitin proteasome system in Alzheimer's diseaseSemantic proximity Read ↗

Age-related changes in Tau and Autophagy in human brain in the absence of neurodegenerationSemantic proximity Read ↗

Age-related changes in tau and autophagy in human brain in the absence of neurodegenerationSemantic proximity Read ↗

Important neuronal toxicity of microtubule-bound Tau in vivo in DrosophilaSemantic proximity Read ↗

Loss of Tau results in defects in photoreceptor development and progressive neuronal degeneration in Drosophila.Semantic proximity Read ↗

The ubiquitin‐proteasome system in Alzheimer's diseaseSemantic proximity Read ↗

Deletion of endogenous Tau proteins is not detrimental in DrosophilaSemantic proximity Read ↗

Involvement of puromycin-sensitive aminopeptidase in proteolysis of tau protein in cultured cells, and attenuated proteolysis of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) mutant tau.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.