Article
A caspase cleaved form of tau is preferentially degraded through the autophagy pathway.
The Journal of biological chemistry - 16 Jul 2010
Dolan Philip J, Johnson Gail V W
Abstract excerpt
The microtubule-associated protein tau plays a central role in the pathogenesis of Alzheimer disease (AD) and abnormally accumulates as neurofibrillary tangles; therefore, the pathways by which tau is degraded have been examined extensively. In AD brain tau is abnormally truncated at Asp(421) (tauDeltaC), which increases its fibrillogenic properties and results in compromised neuronal function. Given the fact...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.