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Article

ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes.

Diabetes - 1 Apr 2005

Abate Nicola, Chandalia Manisha, Satija Pankaj, Adams-Huet Beverley, Grundy Scott M, Sandeep Sreedharan, Radha Venkatesan, Deepa Raj, Mohan Viswanathan

Abstract excerpt

Genetic susceptibility modulates the impact of obesity on risk for type 2 diabetes. The present study evaluates the role of ENPP1 K121Q polymorphism in prediction of type 2 diabetes in three populations that differ in susceptibility to diabetes and environmental exposure. The three cohorts included 679 nonmigrant South Asians living in Chennai, India (223 with type 2 diabetes); 1,083 migrant South Asians living...

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Identifiers

PMID: 15793263
DOI: 10.2337/diabetes.54.4.1207

Genes

ENPP1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes.PMID 15793263Read ↗

ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes in North Indians.Semantic proximity Read ↗

Ethnic differences in the frequency of ENPP1/PC1 121Q genetic variant in the Dallas Heart Study cohort.Semantic proximity Read ↗

Effect of ENPP1/PC-1-K121Q and PPARgamma-Pro12Ala polymorphisms on the genetic susceptibility to T2D in the Tunisian population.Semantic proximity Read ↗

ENPP1 121Q functional variant enhances susceptibility to coronary artery disease in South Indian patients with type 2 diabetes mellitus.Semantic proximity Read ↗

Genetic polymorphism PC-1 K121Q and ethnic susceptibility to insulin resistance.Semantic proximity Read ↗

The K121Q polymorphism of the ENPP1/PC-1 gene is associated with insulin resistance/atherogenic phenotypes, including earlier onset of type 2 diabetes and myocardial infarction.Semantic proximity Read ↗

K121Q ENPP1/PC-1 gene polymorphism is associated with insulin resistance in a North Indian population.Semantic proximity Read ↗

The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects.Semantic proximity Read ↗

Association of the ENPP1 K121Q polymorphism with susceptibility to type 2 diabetes in different populations: evidence based on 40 studies.Semantic proximity Read ↗

The ENPP1 K121Q polymorphism determines individual susceptibility to the insulin-sensitising effect of lifestyle intervention.Semantic proximity Read ↗

The role of K121Q ENPP1 polymorphism in diabetes mellitus and its complications.Semantic proximity Read ↗

No evidence for association of the ENPP1 (PC-1) K121Q variant with risk of type 2 diabetes in a Japanese population.Semantic proximity Read ↗

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