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Article

No evidence for association of the ENPP1 (PC-1) K121Q variant with risk of type 2 diabetes in a Japanese population.

Journal of human genetics - 1 Jan 2006

Keshavarz Parvaneh, Inoue Hiroshi, Sakamoto Yukiko, Kunika Kiyoshi, Tanahashi Toshihito, Nakamura Naoto, Yoshikawa Toshikazu, Yasui Natsuo, Shiota Hiroshi, Itakura Mitsuo

Abstract excerpt

Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1, also known as PC-1) inhibits insulin signal transduction pathway(s). Previous studies have demonstrated the K121Q variant of the ENPP1 gene to have a significant functional role in determining susceptibility to insulin resistance and type 2 diabetes (T2D). To assess whether the K121Q variant has any impact on T2D in Japanese, we undertook an extensive...

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Identifiers

PMID: 16607460
DOI: 10.1007/s10038-006-0399-0

Genes

ENPP1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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No evidence for association of the ENPP1 (PC-1) K121Q variant with risk of type 2 diabetes in a Japanese population.PMID 16607460Read ↗

The ENPP1 K121Q polymorphism is not associated with type 2 diabetes in northern Chinese.Semantic proximity Read ↗

Association of the ENPP1 K121Q polymorphism with susceptibility to type 2 diabetes in different populations: evidence based on 40 studies.Semantic proximity Read ↗

ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes in North Indians.Semantic proximity Read ↗

ENPP1 K121Q polymorphism and type 2 diabetes mellitus in the Chinese population: a meta-analysis including 11,855 subjects.Semantic proximity Read ↗

New polymorphism of ENPP1 (PC-1) is associated with increased risk of type 2 diabetes among obese individuals.Semantic proximity Read ↗

The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects.Semantic proximity Read ↗

The ENPP1 K121Q polymorphism is not associated with type 2 diabetes and related metabolic traits in an Iranian population.Semantic proximity Read ↗

The ENPP1 K121Q polymorphism is not associated with type 2 diabetes or obesity in the Chinese Han population.Semantic proximity Read ↗

Ethnic differences in the frequency of ENPP1/PC1 121Q genetic variant in the Dallas Heart Study cohort.Semantic proximity Read ↗

The K121Q polymorphism of the ENPP1/PC-1 gene is associated with insulin resistance/atherogenic phenotypes, including earlier onset of type 2 diabetes and myocardial infarction.Semantic proximity Read ↗

ENPP1/PC-1 gene K121Q polymorphism is associated with obesity in European adult populations: evidence from a meta-analysis involving 24,324 subjects.Semantic proximity Read ↗

Haplotype structure of the ENPP1 Gene and Nominal Association of the K121Q missense single nucleotide polymorphism with glycemic traits in the Framingham Heart Study.Semantic proximity Read ↗

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