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Article

Structural insights into the activity of enhancer-binding proteins.

Science (New York, N.Y.) - 25 Mar 2005

Rappas Mathieu, Schumacher Jorg, Beuron Fabienne, Niwa Hajime, Bordes Patricia, Wigneshweraraj Sivaramesh, Keetch Catherine A, Robinson Carol V, Buck Martin, Zhang Xiaodong

Abstract excerpt

Activators of bacterial sigma54-RNA polymerase holoenzyme are mechanochemical proteins that use adenosine triphosphate (ATP) hydrolysis to activate transcription. We have determined by cryogenic electron microscopy (cryo-EM) a 20 angstrom resolution structure of an activator, phage shock protein F [PspF(1-275)], which is bound to an ATP transition state analog in complex with its basal factor, sigma54. By fitting...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15790859
DOI: 10.1126/science.1105932
PMCID: PMC2756573

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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