Article
Analysis of somatic molecular changes, clinicopathological features, family history, and germline mutations in colorectal cancer families: evidence for efficient diagnosis of HNPCC and for the existence of distinct groups of non-HNPCC families.
Journal of medical genetics - 1 Oct 2005
Johnson V, Lipton L R, Cummings C, Eftekhar Sadat A T, Izatt L, Hodgson S V, Talbot I C, Thomas H J W, Silver A J R, Tomlinson I P M
Abstract excerpt
OBJECTIVE: To analyse somatic molecular changes, clinicopathological features, family history, and germline mutations in families with colorectal cancer (CRC). METHODS: Molecular changes (K-ras and beta-catenin mutations, chromosome 18q allele loss (LOH), APC LOH, microsatellite instability (MSI), and expression of beta-catenin and p53) were examined in four series of CRC patients with proven or probable...
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