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Article

Chemical rescue of histidine selectivity filter mutants of the M2 ion channel of influenza A virus.

The Journal of biological chemistry - 3 Jun 2005

Venkataraman Padmavati, Lamb Robert A, Pinto Lawrence H

Abstract excerpt

The influenza virus M2 proton-selective ion channel activity facilitates virus uncoating, a process that occurs in the acidic environment of the endosome. The M2 channel causes acidification of the interior of the virus particle, which results in viral protein-protein dissociation. The M2 protein is a homotetramer that contains in its aqueous pore a histidine residue (His-37) that acts as a selectivity filter and...

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PMID: 15784624
DOI: 10.1074/jbc.M412406200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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