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Article

The gate of the influenza virus M2 proton channel is formed by a single tryptophan residue.

The Journal of biological chemistry - 18 Oct 2002

Tang Yajun, Zaitseva Florina, Lamb Robert A, Pinto Lawrence H

Abstract excerpt

The influenza virus M2 proton-selective ion channel is known to be essential for acidifying the interior of virions during virus uncoating in the lumen of endosomes. The M2 protein is a homotetramer that contains four 19-residue transmembrane (TM) domains. These TM domains are multifunctional, because they contain the channel pore and also anchor the protein in membranes. The M2 protein is gated by pH, and thus...

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Identifiers

PMID: 12183461
DOI: 10.1074/jbc.M206582200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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