Article
High pressure liquid chromatography and electrospray ionization mass spectrometry are advantageously integrated into a two-levels approach to detection and identification of haemoglobin variants.
Clinical and laboratory haematology - 1 Apr 2005
Caruso D, Crestani M, Mitro N, Da Riva L, Mozzi R, Sarpau S, Merlotti C, Franzini C
Abstract excerpt
Detecting and correctly identifying haemoglobin (Hb) variants is typically achieved by a two-levels laboratory approach. We report our experience in dealing with 91 Hb variants, including a number of frequent and a few rare variants. Screening included akaline agarose gel electrophoresis (AGE), ion-exchange automated high-performance liquid chromatography (HPLC) and a test for deoxyhaemoglobin solubility....
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