Article
Experimental designs for reliable detection of linkage disequilibrium in unstructured random population association studies.
Genetics - 1 Jun 2005
Ball Roderick D
Abstract excerpt
A method is given for design of experiments to detect associations (linkage disequilibrium) in a random population between a marker and a quantitative trait locus (QTL), or gene, with a given strength of evidence, as defined by the Bayes factor. Using a version of the Bayes factor that can be linked to the value of an F-statistic with an existing deterministic power calculation makes it possible to rapidly...
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