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Article

Pharmacogenomics of the RNA world: structural RNA polymorphisms in drug therapy.

Clinical pharmacology and therapeutics - 1 Mar 2011

Sadee W, Wang D, Papp A C, Pinsonneault J K, Smith R M, Moyer R A, Johnson A D

Abstract excerpt

The use of pharmacogenomic biomarkers can enhance treatment outcomes. Regulatory polymorphisms are promising biomarkers that have proven difficult to uncover. They come in two flavors: those that affect transcription (regulatory single-nucleotide polymorphisms (rSNPs)) and those that affect RNA functions such as splicing, turnover, and translation (termed structural RNA SNPs (srSNPs)). This review focuses on the...

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PMID: 21289622
DOI: 10.1038/clpt.2010.314
PMCID: PMC3251919

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