Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Haplotype-dependent binding of nuclear proteins to the promoter of the neural tube defects-associated platelet-derived growth factor alpha-receptor gene.

Biochimica et biophysica acta - 25 Sept 2005

Toepoel Mascha, Ackerschott Bart, van Zoelen Everardus J J

Abstract excerpt

We have previously shown that polymorphisms in the promoter of the human platelet-derived growth factor alpha-receptor (PDGFRA) gene can be grouped into five distinct haplotypes, designated H1, H 2 alpha, H 2 beta, H 2 gamma and H 2 delta, and that specific combinations of these promoter haplotypes predispose to neural tube defects (NTDs). These promoter haplotypes differ strongly in their ability to drive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to DNA Primers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophoretic Mobility Shift Assay

Share to Haplotypes

Share to Neural Tube Defects

Share to Promoter Regions, Genetic

Share to Receptor, Platelet-Derived Growth Factor alpha

Share to Transcription Factors

Source

Identifiers

PMID: 16126374
DOI: 10.1016/j.bbadis.2005.08.001

Genes

PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Haplotype-dependent binding of nuclear proteins to the promoter of the neural tube defects-associated platelet-derived growth factor alpha-receptor gene.PMID 16126374Read ↗

Promoter haplotype combinations of the platelet-derived growth factor alpha-receptor gene predispose to human neural tube defects.Semantic proximity Read ↗

Haplotype-specific expression of the human PDGFRA gene correlates with the risk of glioblastomas.Semantic proximity Read ↗

Puralpha activates PDGF-A gene transcription via interactions with a G-rich, single-stranded region of the promoter.Semantic proximity Read ↗

A PDGFRA promoter polymorphism, which disrupts the binding of ZNF148, is associated with primitive neuroectodermal tumours and ependymomas.Semantic proximity Read ↗

Specific protein-1 is a universal regulator of UDP-glucose dehydrogenase expression: its positive involvement in transforming growth factor-beta signaling and inhibition in hypoxia.Semantic proximity Read ↗

Transcriptional regulation of a new variant of human platelet-derived growth factor receptor alpha transcript by E2F-1.Semantic proximity Read ↗

Structural and functional characterization of the human PAX7 5'-flanking regulatory region.Semantic proximity Read ↗

Identification and functional analyses of polymorphism haplotypes of protein phosphatase 2A-Aα gene promoter.Semantic proximity Read ↗

Allele-dependent transcriptional regulation of the human integrin alpha2 gene.Semantic proximity Read ↗

Pit-1 Binding Sites at the Somatotrope-specific DNase I Hypersensitive Sites I, II of the Human Growth Hormone Locus Control Region Are Essential for in Vivo hGH-N Gene ActivationSemantic proximity Read ↗

Enhanced binding of poly(ADP-ribose)polymerase-1 and Ku80/70 to the ITGA2 promoter via an extended cytosine-adenosine repeat.Semantic proximity Read ↗

Induction of Phosphoglycerate Kinase 1 Gene Expression by HypoxiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.