Article
Maintenance of neuronal positions in organized ganglia by SAX-7, a Caenorhabditis elegans homologue of L1.
The EMBO journal - 6 Apr 2005
Sasakura Hiroyuki, Inada Hitoshi, Kuhara Atsushi, Fusaoka Eri, Takemoto Daisuke, Takeuchi Kosei, Mori Ikue
Abstract excerpt
The L1 family of cell adhesion molecules is predominantly expressed in the nervous system. Mutations in human L1 cause neuronal diseases such as HSAS, MASA, and SPG1. Here we show that sax-7 gene encodes an L1 homologue in Caenorhabditis elegans. In sax-7 mutants, the organization of ganglia and positioning of neurons are abnormal in the adult stage, but these abnormalities are not observed in early larval stage....
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